What is Toad Medicine? The milky white substance that is excreted from the parotoid glands of the Sonoran Desert Toad. The substance can be collected with human manipulation, dried, and smoked for profound psychedelic experiences. The medicine is short-acting and ranges from 15-45 minutes in length. The effects of smoking toad medicine include ego dissolution, deep emotional release, feelings of leaving the physical body, and can sometimes include spiritual visions.